Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genomic Organization and Functional Analysis of Murine PKD2L1

18 Nov 2004

Abstract excerpt

Mutations in genes that encode polycystins 1 or 2 cause polycystic kidney disease (PKD). Here, we report the genomic organization and functional expression of murine orthologue of human polycystin-2L1 (PKD2L1). The murine PKD2L1 gene comprises 15 exons in chromosome 19C3. Coexpression of PKD2L1 together with polycystin-1 (PKD1) resulted in the expression of PKD2L1 channels on the cell surface, whereas PKD2L1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomedical Research and Pathophysiology
Share to Genetic and Kidney Cyst Diseases
Share to Genetic Syndromes and Imprinting

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15548533
DOI: 10.1074/jbc.m411496200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomic Organization and Functional Analysis of Murine PKD2L1PMID 15548533Read ↗

Molecular basis of polycystic kidney disease: PKD1, PKD2 and PKHD1.Semantic proximity Read ↗

The polycystins: a novel class of membrane-associated proteins involved in renal cystic disease.Semantic proximity Read ↗

The TRPP subfamily and polycystin-1 proteins.Semantic proximity Read ↗

Autosomal dominant polycystic kidney disease: clues to pathogenesis.Semantic proximity Read ↗

Transport function of the naturally occurring pathogenic polycystin-2 mutant, R742X.Semantic proximity Read ↗

PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein.Semantic proximity Read ↗

PKHDL1, a homolog of the autosomal recessive polycystic kidney disease gene, encodes a receptor with inducible T lymphocyte expression.Semantic proximity Read ↗

A polycystin-centric view of cyst formation and disease: the polycystins revisited.Semantic proximity Read ↗

Structural studies of the C‐terminal tail of polycystin‐2 (PC2) reveal insights into the mechanisms used for the functional regulation of PC2Semantic proximity Read ↗

A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes.Semantic proximity Read ↗

Functionally conserved Pkd2, mutated in autosomal dominant polycystic kidney disease, localizes to the endoplasmic reticulum and regulates cytoplasmic calcium homeostasis in fission yeastSemantic proximity Read ↗

Polycystin-2 (PC2): structural insights and its role in disease pathogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.