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Targeting QKI-7 in vivo restores endothelial cell function in diabetes

30 Jul 2020

Abstract excerpt

Vascular endothelial cell (EC) dysfunction plays a key role in diabetic complications. This study discovers significant upregulation of Quaking-7 (QKI-7) in iPS cell-derived ECs when exposed to hyperglycemia, and in human iPS-ECs from diabetic patients. QKI-7 is also highly expressed in human coronary arterial ECs from diabetic donors, and on blood vessels from diabetic critical limb ischemia patients undergoing...

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PMID: 32732889
DOI: 10.1038/s41467-020-17468-y

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