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APOE-<i>ε4</i>Modulates Facial Neuromuscular Activity in Nondemented Adults: Toward Sensitive Speech-Based Diagnostics for Alzheimer’s Disease

2025-04-29

Abstract excerpt

The APOE-ε4 allele is a genetic risk factor for late-onset Alzheimer’s disease (AD). Beyond cognitive decline, APOE-ε4 affects motor function, reducing muscle strength and coordination, potentially through mitochondrial dysfunction and oxidative stress. This study examined the influence of the APOE- ε4 allele on neuromuscular function in oral muscles involved in speech production, using surface electromyography (E...

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Literature Corpus work
77913f14-be0f-50ce-89bc-e00a910b224a
DOI
10.1101/2025.04.29.25326665
Open publication

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APOE-<i>ε4</i>Modulates Facial Neuromuscular Activity in Nondemented Adults: Toward Sensitive Speech-Based Diagnostics for Alzheimer’s DiseaseDOI 10.1101/2025.04.29.25326665
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