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Article

Resting-state brain signal complexity discriminates young healthy APOE e4 carriers from non-e4 carriers.

The European journal of neuroscience - 1 Mar 2023

Li Xiaojing, Kaur Yadwinder, Wilhelm Oliver, Reuter Martin, Montag Christian, Sommer Werner, Zhou Changsong, Hildebrandt Andrea

Abstract excerpt

It is well established that the e4 allele of the APOE gene is associated with impaired brain functionality and cognitive decline in humans at elder age. However, it is controversial whether and how the APOE e4 allele is associated with superior brain function among young healthy individuals, thus indicates a case of antagonistic pleiotropy of APOE e4 allele. Signal complexity is a critical aspect of brain...

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PMID: 36656069
DOI: 10.1111/ejn.15915

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