Article

Detecting Preclinical Alzheimer’s Disease Risk in Cognitively Normal Adults Using Speech Acoustics: Validation with Plasma p-Tau217 and APOE-ε4 Status

2026-01-16

Abstract excerpt

<h4>ABSTRACT</h4> <h4>INTRODUCTION</h4> We tested whether spontaneous speech acoustics provide a scalable digital marker of biologically defined Alzheimer’s disease (AD) risk. <h4>METHODS</h4> Forty-nine cognitively unimpaired older adults were stratified within APOE genotype into Low-, Moderate-, and High-Risk groups based on log₁₀-transformed plasma p-tau217. Acoustic features were extracted from spontaneous...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 111b38bc-9642-5011-84ec-635af46acd92
DOI: 10.64898/2026.01.15.26344226

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Detecting Preclinical Alzheimer’s Disease Risk in Cognitively Normal Adults Using Speech Acoustics: Validation with Plasma p-Tau217 and APOE-ε4 StatusDOI 10.64898/2026.01.15.26344226Read

Speech Acoustic Markers Detect APOE-ε4 Carrier Status in Cognitively Healthy IndividualsSemantic proximity Read

Linguistic and Acoustic Biomarkers from Simulated Speech Reveal Early Cognitive Impairment Patterns in Alzheimer’s DiseaseSemantic proximity Read

Evaluation of a speech-based AI system for early detection of Alzheimer’s disease remotely via smartphonesSemantic proximity Read

Lexical and acoustic speech features relating to Alzheimer’s disease pathologySemantic proximity Read

Clinically meaningful metrics of speech in neurodegenerative disease: Quantification of speech intelligibility and naturalness in ataxiaSemantic proximity Read

Automatic classification of AD pathology in FTD phenotypes using natural speech.Semantic proximity Read

Automatic speech recognition alters diagnostic error and biomarker validity in AI-based dementia speech assessmentSemantic proximity Read

Acoustic Analysis of Primary Care Patient-provider Conversations to Screen for Cognitive ImpairmentSemantic proximity Read

Detection of Amyotrophic Lateral Sclerosis (ALS) via Acoustic AnalysisSemantic proximity Read

Comprehension of acoustically degraded speech in Alzheimer’s disease and primary progressive aphasiaSemantic proximity Read

A Systematic Review of the Quantitative markers of speech and language of the Frontotemporal Degeneration Spectrum and their potential for cross-linguistic implementationSemantic proximity Read

Digital language markers distinguish frontal from right anterior temporal lobe atrophy in frontotemporal dementiaSemantic proximity Read