Article

Speech Acoustic Markers Detect APOE-ε4 Carrier Status in Cognitively Healthy Individuals

2025-10-05

Abstract excerpt

<h4>Background</h4> APOE-ε4, the strongest genetic risk factor for Alzheimer’s disease (AD), is linked to early motor vulnerability, including subtle speech control changes. Because speech integrates fine neuromotor processes, acoustic analysis could offer a sensitive, noninvasive marker of preclinical effects. <h4>Objectives</h4> To determine if speech acoustics distinguish cognitively healthy APOE-ε4 carriers...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 142c31a4-5265-5ff5-8032-f251f6ab0d8c
DOI: 10.1101/2025.10.03.25337276

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Speech Acoustic Markers Detect APOE-ε4 Carrier Status in Cognitively Healthy IndividualsDOI 10.1101/2025.10.03.25337276Read

Detecting Preclinical Alzheimer’s Disease Risk in Cognitively Normal Adults Using Speech Acoustics: Validation with Plasma p-Tau217 and APOE-ε4 StatusSemantic proximity Read

APOE-<i>ε4</i>Modulates Facial Neuromuscular Activity in Nondemented Adults: Toward Sensitive Speech-Based Diagnostics for Alzheimer’s DiseaseSemantic proximity Read

Clinically meaningful metrics of speech in neurodegenerative disease: Quantification of speech intelligibility and naturalness in ataxiaSemantic proximity Read

Linguistic and Acoustic Biomarkers from Simulated Speech Reveal Early Cognitive Impairment Patterns in Alzheimer’s DiseaseSemantic proximity Read

Acoustic Analysis of Primary Care Patient-provider Conversations to Screen for Cognitive ImpairmentSemantic proximity Read

Genetic risk score for Alzheimer’s disease is associated with poor hearingSemantic proximity Read

Automated and objective analysis of speech in premanifest and early-stage Huntington’s diseaseSemantic proximity Read

A Systematic Review of the Quantitative markers of speech and language of the Frontotemporal Degeneration Spectrum and their potential for cross-linguistic implementationSemantic proximity Read

A genome-wide association study reveals a polygenic architecture of speech-in-noise deficits in individuals with self-reported normal hearing.Semantic proximity Read

Lexical and acoustic speech features relating to Alzheimer’s disease pathologySemantic proximity Read

Sound-evoked auditory neurophysiological signals are a window into prodromal functional differences in a preclinical model of Alzheimer′s DiseaseSemantic proximity Read

Automatic classification of AD pathology in FTD phenotypes using natural speech.Semantic proximity Read