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Article

Reduced physiological complexity in robust elderly adults with the APOE epsilon4 allele.

PloS one - 5 Nov 2009

Cheng Daniel, Tsai Shih-Jen, Hong Chen-Jee, Yang Albert C

Abstract excerpt

BACKGROUND: It is unclear whether the loss of physiological complexity during the aging process is due to genetic variations. The APOE gene has been studied extensively in regard to its relationship with aging-associated medical illness. We hypothesize that diminished physiological complexity, as measured by heart rate variability, is influenced by polymorphisms in the APOE allele among elderly individuals....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19890394
DOI: 10.1371/journal.pone.0007733
PMCID: PMC2767503

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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