Article

Spatiotemporal expression of Rest in the brain of Ts1Cje mouse model of Down syndrome

2023-01-23

Abstract excerpt

<h4>Introduction: </h4> Down syndrome (DS) is a common genetic disorder caused by full or partial trisomy of human chromosome 21. DS individuals usually have poor neurological development with neuropsychiatric manifestations. Repressor element-1 silencing transcription factor (REST) is the key regulator for epigenetic neuronal gene expression. REST nuclear translocation is crucial to exert repression on target gen...

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Literature Corpus work: 6e52fb7b-a3b3-594e-8916-2f3b536bac65
DOI: 10.21203/rs.3.rs-2492451/v1

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