Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease

Abstract excerpt

BACKGROUND: The incidence of non-alcoholic fatty liver disease (NAFLD)-associated hepatocellular carcinoma (HCC) is increasing worldwide, but the steps in precancerous hepatocytes which lead to HCC driver mutations are not well understood. Here we provide evidence that metabolically driven histone hyperacetylation in steatotic hepatocytes can increase DNA damage to initiate carcinogenesis. METHODS: Global...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Alcohol Consumption and Health Effects
• Share to Cancer, Hypoxia, and Metabolism
• Share to Liver Disease Diagnosis and Treatment