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Article

<i>SUMO-1</i> Gene Transfer Improves Cardiac Function in a Large-Animal Model of Heart Failure

13 Nov 2013

Abstract excerpt

Recently, the impact of small ubiquitin-related modifier 1 (SUMO-1) on the regulation and preservation of sarcoplasmic reticulum calcium adenosine triphosphatase (SERCA2a) function was discovered. The amount of myocardial SUMO-1 is decreased in failing hearts, and its knockdown results in severe heart failure (HF) in mice. In a previous study, we showed that SUMO-1 gene transfer substantially improved cardiac...

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PMID: 24225946
DOI: 10.1126/scitranslmed.3006487

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