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RV-specific Targeting of Snai1 Rescues Pulmonary Hypertension-induced Right Ventricular Failure by Inhibiting EndMT and Fibrosis <i>via</i> LOXL2 Mediated Mechanism

2024-05-03

Abstract excerpt

<h4>Background</h4> Pulmonary hypertension (PH)-induced right ventricular (RV) failure (PH-RVF) is a significant prognostic determinant of mortality and is characterized by RV hypertrophy, endothelial-to-mesenchymal transition (EndMT), fibroblast-to-myofibroblast transition (FMT), fibrosis, and extracellular matrix (ECM)-remodeling. Despite the importance of RV function in PH, the mechanistic details of PH-RVF, e...

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Literature Corpus work
eafa575d-a1b5-5c88-8ead-53cf19d407e3
DOI
10.1101/2024.04.30.591766
Open publication

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RV-specific Targeting of Snai1 Rescues Pulmonary Hypertension-induced Right Ventricular Failure by Inhibiting EndMT and Fibrosis <i>via</i> LOXL2 Mediated MechanismDOI 10.1101/2024.04.30.591766
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