Genome-wide analysis of 439 mass spectrometry-based proteomic profiles in a population of 15,035 Scottish individuals

Abstract excerpt

Understanding the genetic architecture of the circulating proteome can help determine if a protein is causally linked to disease. Previous large-scale genome-wide association studies (GWAS) of proteins have mostly been conducted to pre-defined, targeted subsets of the proteome, and have often concentrated on low abundance proteins, many of which don’t exert their main function in serum. Mass spectrometry-based pro...

Topics

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• Gene Ontology
• Mendelian Randomization Analysis
• Molecular Sequence Annotation
• Parkinson Disease
• Proteome
• Scavenger Receptors, Class A
• Sialic Acid Binding Ig-like Lectin 3
• Whole Genome Sequencing

Identifiers and source

Literature Corpus work

77248bbf-6a5b-56ab-a9d6-6818d7355b18

DOI

10.1101/2025.08.14.25333677