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Article

Mapping the serum proteome to neurological diseases using whole genome sequencing.

Nature communications - 2 Dec 2021

Png Grace, Barysenka Andrei, Repetto Linda, Navarro Pau, Shen Xia, Pietzner Maik, Wheeler Eleanor, Wareham Nicholas J, Langenberg Claudia, Tsafantakis Emmanouil, Karaleftheri Maria, Dedoussis George, Mälarstig Anders, Wilson James F, Gilly Arthur, Zeggini Eleftheria

Abstract excerpt

Despite the increasing global burden of neurological disorders, there is a lack of effective diagnostic and therapeutic biomarkers. Proteins are often dysregulated in disease and have a strong genetic component. Here, we carry out a protein quantitative trait locus analysis of 184 neurologically-relevant proteins, using whole genome sequencing data from two isolated population-based cohorts (N = 2893). In doing...

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Identifiers

PMID: 34857772
DOI: 10.1038/s41467-021-27387-1
PMCID: PMC8640022

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