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Engineered colorectal cancer tissue recapitulates key attributes of a patient-derived xenograft tumor line

26 May 2022

Abstract excerpt

Abstract The development of physiologically relevant in vitro colorectal cancer (CRC) models is vital for advancing understanding of tumor biology. Although CRC patient-derived xenografts (PDXs) recapitulate key patient tumor characteristics and demonstrate high concordance with clinical outcomes, the use of this in vivo model is costly and low-throughput. Here we report the establishment and in-depth...

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PMID: 35617932
DOI: 10.1088/1758-5090/ac73b6

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