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Methylglyoxal-Induced Modifications in Human Triosephosphate Isomerase: Structural and Functional Repercussions of Specific Mutations.

Molecules (Basel, Switzerland) - 25 Oct 2024

de la Mora-de la Mora Ignacio, García-Torres Itzhel, Flores-López Luis Antonio, López-Velázquez Gabriel, Hernández-Alcántara Gloria, Gómez-Manzo Saúl, Enríquez-Flores Sergio

Abstract excerpt

Triosephosphate isomerase (TPI) dysfunction is a critical factor in diverse pathological conditions. Deficiencies in TPI lead to the accumulation of toxic methylglyoxal (MGO), which induces non-enzymatic post-translational modifications, thus compromising protein stability and leading to misfolding. This study investigates how specific TPI mutations (E104D, N16D, and C217K) affect the enzyme's structural...

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PMID: 39519689
DOI: 10.3390/molecules29215047
PMCID: PMC11547674

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