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Article

Deamidated Human Triosephosphate Isomerase is a Promising Druggable Target.

Biomolecules - 15 Jul 2020

Enríquez-Flores Sergio, Flores-López Luis Antonio, García-Torres Itzhel, de la Mora-de la Mora Ignacio, Cabrera Nallely, Gutiérrez-Castrellón Pedro, Martínez-Pérez Yoalli, López-Velázquez Gabriel

Abstract excerpt

Therapeutic strategies for the treatment of any severe disease are based on the discovery and validation of druggable targets. The human genome encodes only 600-1500 targets for small-molecule drugs, but posttranslational modifications lead to a considerably larger druggable proteome. The spontaneous conversion of asparagine (Asn) residues to aspartic acid or isoaspartic acid is a frequent modification in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Small Molecule Libraries

Triose-Phosphate Isomerase

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PMID: 32679775
DOI: 10.3390/biom10071050
PMCID: PMC7407242

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