Article

Beyond SNP Heritability: Polygenicity and Discoverability of Phenotypes Estimated with a Univariate Gaussian Mixture Model

2018-12-17

Abstract excerpt

Of signal interest in the genetics of human traits is estimating their polygenicity (the proportion of causally associated single nucleotide polymorphisms (SNPs)) and the discoverability (or effect size variance) of the causal SNPs. Narrow-sense heritability is proportional to the product of these quantities. We present a basic model, using detailed linkage disequilibrium structure from an extensive reference pane...

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Literature Corpus work: 4502536a-9dd1-56c0-88f3-7c01a7c3b6dd
DOI: 10.1101/498550

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