Article
Transport dynamics in a glutamate transporter homologue.
Nature - 3 Oct 2013
Akyuz Nurunisa, Altman Roger B, Blanchard Scott C, Boudker Olga
Abstract excerpt
Glutamate transporters are integral membrane proteins that catalyse neurotransmitter uptake from the synaptic cleft into the cytoplasm of glial cells and neurons. Their mechanism of action involves transitions between extracellular (outward)-facing and intracellular (inward)-facing conformations, whereby substrate binding sites become accessible to either side of the membrane. This process has been proposed to...
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