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Natural microbial exposure populates the maternal fetal interface with diverse T cells

9 Jul 2025

Abstract excerpt

Diverse T cell types accumulate at the human maternal fetal interface (MFI) during pregnancy to orchestrate immune tolerance for foreign fetal/placental tissues and immunity to pathogens. Yet, the dynamics of T cell influx and function at the MFI remain poorly defined. Conventional specific pathogen free (SPF) murine models fail to replicate the number and diversity of T cells in the human MFI, hindering...

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PMID: 40703520
DOI: 10.3389/fimmu.2025.1616491

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