Article

The plasma membrane as a competitive inhibitor and positive allosteric modulator of KRas4B signaling

2019-10-17

Abstract excerpt

Mutant Ras proteins are important drivers of human cancers, yet no approved drugs act directly on this difficult target. Over the last decade, the idea has emerged that oncogenic signaling can be diminished by molecules that drive Ras into orientations in which effector binding interfaces are occluded by the cell membrane. To support this approach to drug discovery, we characterize the orientational preferences of...

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Literature Corpus work: bcb33281-aced-58cd-8634-4345c4f4cec8
DOI: 10.1101/809616

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