Article

A visual atlas of genes’ tissue-specific pathological roles

2022-01-10

Abstract excerpt

Dysregulation of a gene’s function, either due to mutations or impairments in regulatory networks, often triggers pathological states in the affected tissue. Comprehensive mapping of these apparent gene-pathology relationships is an ever daunting task, primarily due to genetic pleiotropy and lack of suitable computational approaches. With the advent of high throughput genomics platforms and community scale initiat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7641c89f-ea84-5ef1-9672-57d14be6bb60
DOI: 10.1101/2022.01.08.475476

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A visual atlas of genes’ tissue-specific pathological rolesDOI 10.1101/2022.01.08.475476Read

HCNetlas: Human cell network atlas enabling cell type-resolved disease geneticsSemantic proximity Read

STARNet enables spatially resolved inference of gene regulatory networks from spatial multi-omics dataSemantic proximity Read

Molecular maps of diseases from omics data and network embeddingsSemantic proximity Read

An integrative tissue-network approach to identify and test human disease genesSemantic proximity Read

Exploring the cellular basis of human disease through a large-scale mapping of deleterious genes to cell types.Semantic proximity Read

Tissue Specificity of Human Disease Module.Semantic proximity Read

Spatial transcriptomics and genetically implicated genes identify putative causal tissue structures for complex traitsSemantic proximity Read

singIST: an R/Bioconductor library and Quarto dashboard for automated single-cell comparative transcriptomics analysis of disease models and humansSemantic proximity Read

An atlas of tissue-specific conserved coexpression for functional annotation and disease gene prediction.Semantic proximity Read

ChEA-KG: Human Transcription Factor Regulatory Network with a Knowledge Graph Interactive User InterfaceSemantic proximity Read

A novel method to enhance the sensitivity of marker detection using a refined hierarchical prior of tissue similaritiesSemantic proximity Read

Data sources for in vivo molecular profiling of human phenotypes.Semantic proximity Read