Article

ChEA-KG: Human Transcription Factor Regulatory Network with a Knowledge Graph Interactive User Interface

2025-08-12

Abstract excerpt

<h4>ABSTRACT</h4> Gene expression is controlled by transcription factors (TFs) that selectively bind and unbind to DNA to regulate mRNA expression of all human genes. TFs control the expression of other TFs, forming a complex gene regulatory network (GRN) with switches, feedback loops, and other regulatory motifs. Many experimental and computational methods have been developed to reconstruct the human intracellul...

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Literature Corpus work: 4a976c07-c1c2-5de3-b102-5f172472dba8
DOI: 10.1101/2025.08.09.669505

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