Article

XIST Regulates Breast Cancer Stem Cells by Activating Proinflammatory IL-6 Signaling

2022-08-24

Abstract excerpt

<h4>Background: </h4> Aberrant expression of XIST, a long noncoding RNA initiating X chromosome inactivation (XCI) during early embryogenesis, is a common feature of breast cancer (BC). However, the roles of post-XCI XIST in breast carcinogenesis remain elusive. Methods In this study, we examined the expression of XIST in human BC cell (BCC) lines across the spectrum of BC subtypes. We then investigated the effec...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 76364936-e65e-5cc4-91d1-9fcc0b907a20
DOI: 10.21203/rs.3.rs-1975545/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

XIST Regulates Breast Cancer Stem Cells by Activating Proinflammatory IL-6 SignalingDOI 10.21203/rs.3.rs-1975545/v1Read

LncRNA XIST regulates breast cancer stem cells by activating proinflammatory IL-6/STAT3 signaling.Semantic proximity Read

MiR-7 reduces the BCSC subset by inhibiting XIST to modulate the miR-92b/Slug/ESA axis and inhibit tumor growthSemantic proximity Read

Cellular stemness identifies high-risk ductal carcinoma <i>in situ</i> and offers a therapeutic interception opportunitySemantic proximity Read

Prognostic Roles of LncRNA XIST and Its Potential Mechanisms in Human Cancers: A Pan-Cancer AnalysisSemantic proximity Read

The C-X-C Motif Chemokine Ligand 1 Sustains Breast Cancer Stem Cell Self-Renewal and Promotes Tumor Progression and Immune Escape ProgramsSemantic proximity Read

Super-enhancer-hijacking RBBP7 potentiates metastasis and stemness of breast cancer via recruiting NuRD complex subunit LSD1Semantic proximity Read

Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretionSemantic proximity Read

ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype.Semantic proximity Read

XIST and TSIX: Novel Cancer Immune Biomarkers in PD-L1-Overexpressing Breast Cancer PatientsSemantic proximity Read

Super-enhancer-driven ITGA6 enhances stemness features of squamous cell carcinoma through stabilizing c-myc proteinSemantic proximity Read

Defective X Chromosome Inactivation and Cancer Risk in WomenSemantic proximity Read

IL-1-conferred gene expression pattern in ERα+ BCa and AR+ PCa cells is intrinsic to ERα- BCa and AR- PCa cells and promotes cell survivalSemantic proximity Read