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Super-enhancer-driven ITGA6 enhances stemness features of squamous cell carcinoma through stabilizing c-myc protein

2023-07-11

Abstract excerpt

<title>Abstract</title> <p>Squamous cell carcinoma (SCC) is life-threatening malignancy. Cancer stem cells (CSCs) are associated with SCCs initiation, metastasis, therapy resistance, and relapse. Acquisition of super enhancer is a cause of hyper-activation of oncogenes in cancer, contributing to tumorigenesis and progression. In this study, we found disruption of SEs-associated transcription by BRD4 inhibitors JQ...

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Literature Corpus work
06428af9-5dc7-533a-b5a1-4b5425cb9d7b
DOI
10.21203/rs.3.rs-3017766/v1
Open publication

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