Article

Coupling adaptive molecular evolution to phylodynamics using fitness-dependent birth-death models

2019-01-26

Abstract excerpt

Beneficial and deleterious mutations cause fitness to vary among individuals in a population, which natural selection can then act upon to drive adaptive evolution. Non-neutral mutations can likewise cause fitness to vary among lineages in a phylogeny and thereby shape its branching structure. While standard phylogenetic models do not allow mutations to feedback and shape tree topology, birth-death models can acco...

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Literature Corpus work: 76229b80-179d-5d80-b976-090b98a05fce
DOI: 10.1101/531525

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