Article

Mosaic and cocktail capsid-virus-like particle vaccines for induction of antibodies against the EPCR-binding CIDRα1 domain of PfEMP1

2024-04-04

Abstract excerpt

The sequestration of Plasmodium falciparum- infected erythrocytes to the host endothelium is central to the pathogenesis of malaria. The sequestration is mediated by the parasités diverse Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) variants, which bind select human receptors on the endothelium. Severe malaria is associated with PfEMP1 binding human endothelial protein C receptor (EPCR) via thei...

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Literature Corpus work: 61ec81ba-d3b1-5942-bab3-9f4254a1c4e2
DOI: 10.1101/2024.04.02.587801

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