Article

Protective immunity against severe malaria is associated with antibodies to a conserved repertoire of PfEMP1 variants

2018-11-19

Abstract excerpt

Extreme diversity of the major surface antigen and virulence determinant of the malaria parasite Plasmodium falciparum , Erythrocyte Membrane Protein-1 (PfEMP1), poses a major barrier to identifying targets of protective immunity. To overcome this problem, we developed a PfEMP1 protein microarray containing 456 DBLα domains, which was used to characterize the immunome of a cohort of semi-immune children and to id...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0972da5f-b312-5f26-87d0-5456e3550285
DOI: 10.1101/472159

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Protective immunity against severe malaria is associated with antibodies to a conserved repertoire of PfEMP1 variantsDOI 10.1101/472159Read

Protective Immunity against Severe Malaria in Children Is Associated with a Limited Repertoire of Antibodies to Conserved PfEMP1 VariantsSemantic proximity Read

Structural conservation despite huge sequence diversity allows EPCR binding by the PfEMP1 family implicated in severe childhood malaria.Semantic proximity Read

Broadly inhibitory antibodies against severe malaria virulence proteinsSemantic proximity Read

A Plasma Survey Using 38 PfEMP1 Domains Reveals Frequent Recognition of the Plasmodium falciparum Antigen VAR2CSA among Young Tanzanian ChildrenSemantic proximity Read

Longitudinal analysis of naturally acquired antibodies to PfEMP1 CIDR domain variants and their association with malaria protectionSemantic proximity Read

Antibodies to Intercellular Adhesion Molecule 1-Binding Plasmodium falciparum Erythrocyte Membrane Protein 1-DBLβ Are Biomarkers of Protective Immunity to Malaria in a Cohort of Young Children from Papua New Guinea.Semantic proximity Read

The Severity of Plasmodium falciparum Infection Is Associated with Transcript Levels of var Genes Encoding Endothelial Protein C Receptor-Binding P. falciparum Erythrocyte Membrane Protein 1Semantic proximity Read

Plasmodium falciparum var genes expressed in children with severe malaria encode CIDRα1 domainsSemantic proximity Read

Conservation of single amino-acid polymorphisms in <i>Plasmodium falciparum</i> erythrocyte membrane protein 1 and association with severe pathophysiologySemantic proximity Read

Immunization with Recombinant Plasmodium falciparum Erythrocyte Membrane Protein 1 CIDRα1 Domains Induces Domain Subtype Inhibitory Antibodies.Semantic proximity Read

Cytolytic memory CD4 <sup>+</sup> T cell clonotypes are expanded during <i>Plasmodium falciparum</i> infectionSemantic proximity Read

Structure-Guided Identification of a Family of Dual Receptor-Binding PfEMP1 that Is Associated with Cerebral MalariaSemantic proximity Read