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Germline Pathogenic Variants in Breast Cancer-Predisposing Genes Among Early-Onset Female and Male Breast Cancer in Ethiopia.

JCO global oncology - 1 May 2026

Ekdahl Hjelm Tove, Gebremariam Tewodros Yalew, Weldearegay Mahlet Fekadu, Ayele Bethlehem Getachew, Assefa Mathewos, Anberber Endale, Kvist Anders, Törngren Therese, Borg Åke, Margolin Sara, Lindblom Annika, Ashenafi Senait, Löfgren Jenny

Abstract excerpt

PURPOSE: Patients with breast cancer in Ethiopia are generally diagnosed with late-stage disease, and there is a high proportion of young female and male patients. The role of genetic predisposition is yet unknown in this setting. To increase the knowledge about hereditary breast cancer in Ethiopia, this study investigated germline pathogenic variants (PVs) in breast cancer-predisposing genes in a high-risk...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42139642
DOI: 10.1200/GO-25-00699

Genes

BRCA1
PALB2
ATM
BARD1
BRCA2
PTEN
CDH1
CHEK2
RAD51C
RAD51D
STK11
TP53

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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