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Article

Prognostic Impact of Ras Mutation on Surgical Strategy in Rectal Cancer Patients Undergoing Neoadjuvant Treatment.

Anticancer research - 1 May 2023

Orlandi Elena, Romboli Andrea, Citterio Chiara, Trubini Serena, Vecchia Stefano, Palladino Maria Angela, Capelli Patrizio, Cavanna Luigi

Abstract excerpt

BACKGROUND/AIM: Complete clinical response in rectal cancer after neoadjuvant chemo-radiotherapy is challenging. Indeed, indication to surgery vs. "watch and wait" is a debate due the poor predictive value of restaging exams in order to identify a pathological complete response (pCR). Improving the knowledge on mutational pathways such as MAPK/ERK could be helpful in assessing the real impact of disease on...

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PMID: 37097644
DOI: 10.21873/anticanres.16362

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