Article

The molecular basis of Abelson kinase regulation by its αI-helix

2023-10-06

Abstract excerpt

Abelson tyrosine kinase (Abl) is regulated by the arrangement of its regulatory core, consisting sequentially of the SH3, SH2 and kinase (KD) domains, where an assembled or disassembled core corresponds to low or high kinase activity, respectively. It was recently established that binding of type II ATP site inhibitors, such as imatinib, generates a force from the KD N-lobe onto the SH3 domain and in consequence d...

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Literature Corpus work: 759e028c-80b4-5316-9c07-56ff46879461
DOI: 10.1101/2023.10.04.560671

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