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Structure, Regulation, Signaling, and Targeting of Abl Kinases in Cancer

1 May 2012

Abstract excerpt

Abl kinases are prototypic cytoplasmic tyrosine kinases and are involved in a variety of chromosomal aberrations in different cancers. This causes the expression of Abl fusion proteins, such as Bcr-Abl, that are constitutively activated and drivers of tumorigenesis. Over the past decades, biochemical and functional studies on the molecular mechanisms of Abl regulation have gone hand in hand with progression of...

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PMID: 23226581
DOI: 10.1177/1947601912458584

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