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Article

Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation.

Epigenetics - 1 Oct 2014

Tsaprouni Loukia G, Yang Tsun-Po, Bell Jordana, Dick Katherine J, Kanoni Stavroula, Nisbet James, Viñuela Ana, Grundberg Elin, Nelson Christopher P, Meduri Eshwar, Buil Alfonso, Cambien Francois, Hengstenberg Christian, Erdmann Jeanette, Schunkert Heribert, Goodall Alison H, Ouwehand Willem H, Dermitzakis Emmanouil, Spector Tim D, Samani Nilesh J, Deloukas Panos

Abstract excerpt

Smoking is a major risk factor in many diseases. Genome wide association studies have linked genes for nicotine dependence and smoking behavior to increased risk of cardiovascular, pulmonary, and malignant diseases. We conducted an epigenome wide association study in peripheral-blood DNA in 464 individuals (22 current smokers and 263 ex-smokers), using the Human Methylation 450 K array. Upon replication in an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25424692
DOI: 10.4161/15592294.2014.969637
PMCID: PMC4623553

Genes

CHRND
CPOX
GPR15
PRSS23
PSEN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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