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Predicting Thoracic Aortic Dissection in a Diverse Biobank Using a Polygenic Risk Score

1 May 2025

Abstract excerpt

BACKGROUND: Thoracic aortic dissection is a life-threatening condition that often occurs in the presence of aortic dilation. However, currently there are limited clinical risk factors beyond aortic diameter (AoD) used to determine individual-level dissection risk. OBJECTIVES: The purpose of this study was to determine whether common variant genetics can be used to improve identification of individuals most at...

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PMID: 40447339
DOI: 10.1016/j.jacadv.2025.101743

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