Article

Single-cell transcriptome analysis illuminating the characteristics of species-specific innate immune responses against viral infections

2022-12-07

Abstract excerpt

Bats harbor various viruses without severe symptoms and act as their natural reservoirs. The tolerance of bats against viral infections is assumed to originate from the uniqueness of their immune system. However, how immune responses vary between primates and bats remains unclear. Here, we characterized differences in the immune responses by peripheral blood mononuclear cells to various pathogenic stimuli between...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 75230832-5e54-5a0b-a1b5-60475386ff24
DOI: 10.1101/2022.12.06.519403

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell transcriptome analysis illuminating the characteristics of species-specific innate immune responses against viral infectionsDOI 10.1101/2022.12.06.519403Read

Primate innate immune responses to bacterial and viral pathogens reveals an evolutionary trade-off between strength and specificitySemantic proximity Read

Comparison of antiviral responses in two bat species reveals conserved and divergent innate immune pathwaysSemantic proximity Read

A comparative analysis of the antiviral response in two bat species reveals conserved and divergent innate immune pathwaysSemantic proximity Read

Single-cell and Spatial Transcriptomics Illuminate Bat Immunity and Barrier Tissue EvolutionSemantic proximity Read

The IFN response in bat cells consists of canonical and non-canonical ISGs with unique temporal expression kineticsSemantic proximity Read

Dampened STING-Dependent Interferon Activation in Bats.Semantic proximity Read

Human SARS-CoV-2 challenge uncovers local and systemic response dynamicsSemantic proximity Read

Extraordinary diversity of antiviral immune-related gene families across 38 bat species.Semantic proximity Read

Innate Sensing of DNA Virus GenomesSemantic proximity Read

Extensive adaptive changes in bat interferon pathway reveal specific molecular functions at the forefront of host–virus coevolutionSemantic proximity Read

Bat adaptations in inflammation and cell death regulation contribute to viral toleranceSemantic proximity Read

Comparative analysis of single cell lung atlas of bat, cat, tiger and pangolinSemantic proximity Read