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Single-cell and Spatial Transcriptomics Illuminate Bat Immunity and Barrier Tissue Evolution

18 Jan 2025

Abstract excerpt

Bats have adapted to pathogens through diverse mechanisms, including increased resistance-rapid pathogen elimination, and tolerance-limiting tissue damage following infection. In the Egyptian fruit bat (an important model in comparative immunology), several mechanisms conferring disease tolerance were discovered, but mechanisms underpinning resistance remain poorly understood. Previous studies on other species...

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PMID: 39836373
DOI: 10.1093/molbev/msaf017

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