Article

Prognostic Transcriptional Regulatory Programs Reveal Pharmacologically Targetable Vulnerabilities in Treatment-Naive Osteosarcoma

2026-08-26

Abstract excerpt

Osteosarcoma is an aggressive malignancy whose treatment has changed little over the past decades, and outcomes remain poor. Although transcriptomic studies have provided insights into osteosarcoma biology, many include metastatic or post-treatment tumours, potentially obscuring transcriptional programs associated with intrinsic tumour aggressiveness. To address this limitation, we analysed transcriptomic profiles...

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Literature Corpus work: 751ddc33-b32f-50d4-8f43-1d804ae2f0f3
DOI: 10.20944/preprints202608.1928.v1

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