Article
Linoleic acid improves PIEZO2 dysfunction in a mouse model of Angelman Syndrome.
Nature communications - 1 Mar 2023
Romero Luis O, Caires Rebeca, Kaitlyn Victor A, Ramirez Juanma, Sierra-Valdez Francisco J, Walsh Patrick, Truong Vincent, Lee Jungsoo, Mayor Ugo, Reiter Lawrence T, Vásquez Valeria, Cordero-Morales Julio F
Abstract excerpt
Angelman syndrome (AS) is a neurogenetic disorder characterized by intellectual disability and atypical behaviors. AS results from loss of expression of the E3 ubiquitin-protein ligase UBE3A from the maternal allele in neurons. Individuals with AS display impaired coordination, poor balance, and gait ataxia. PIEZO2 is a mechanosensitive ion channel essential for coordination and balance. Here, we report that...
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