Article

Effects of Nicotine Administration on the Expression Levels of alpha7 Nicotinic Acetylcholine Receptor, miRNA-124, STAT3, and Inflammatory Factors in Lung Tissue

2026-03-06

Abstract excerpt

<title>Abstract</title> <p>Background Nicotine, a major alkaloid in tobacco, interacts with nicotinic acetylcholine receptors (nAChRs), notably alpha7 nAChR, which are key modulators of inflammatory signaling. The α7nAChR regulates the release of pro-inflammatory cytokines, a process modulated by microRNA-124 (miR-124), which downregulates inflammatory mediators. Additionally, STAT3, a transcription factor activ...

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Literature Corpus work: 75093bf5-8b0b-5cff-9cff-7b2e49e6ee2e
DOI: 10.21203/rs.3.rs-8899121/v1

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