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Article

Regulatory effect of nicotine on the differentiation of Th1, Th2 and Th17 lymphocyte subsets in patients with rheumatoid arthritis.

European journal of pharmacology - 15 Jul 2018

Wu Shiyao, Zhou Yaou, Liu Sijia, Zhang Huali, Luo Hui, Zuo Xiaoxia, Li Tong

Abstract excerpt

Previous research has demonstrated that nicotine have protective role in rheumatoid arthritis (RA). However, the immunologic mechanisms of nicotine's effect have not been fully elucidated. Herein, the effects of nicotine on the differentiation of Th1, Th2, and Th17 cells were assessed. Peripheral blood mononuclear cells (PBMCs) and CD4+T cells were separated from patients with RA. PBMCs were stimulated with...

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Source

Identifiers

PMID: 29715455
DOI: 10.1016/j.ejphar.2018.04.028

Genes

GATA3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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