Article

Nicotine Changes Airway Epithelial Phenotype and May Increase the SARS-COV2 Infection Severity

2020-12-18

Abstract excerpt

(1) Background: Nicotine is implicated in the SARS-COV-2 infection through activation of the α7-nAChR and over-expression of ACE2. Our objective is to clarify the role of nicotine in SARS-CoV-2 infection exploring its molecular and cellular activity. (2) Methods: HBEpC or si-mRNA-α7-HBEpC were treated for 1, 48 h or continuously with 10-7 M Nicotine, a concentration mimicking human exposure to a cigare...

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Literature Corpus work: f4172cd4-883d-55d7-80db-f3393b097b07
DOI: 10.20944/preprints202012.0467.v1

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