Article
Bone phenotyping of murine hemochromatosis models with deficiencies of Hjv, Alk2, or Alk3: The influence of sex and the bone compartment.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 30 Nov 2024
Dogan Deniz Y, Hornung Isabelle, Pettinato Mariateresa, Pagani Alessia, Baschant Ulrike, Seebohm Guiscard, Hofbauer Lorenz C, Silvestri Laura, Rauner Martina, Steinbicker Andrea U
Abstract excerpt
Osteopenia is frequently observed in patients with iron overload, especially in those with HFE-dependent hereditary hemochromatosis (HH). Interestingly, not all mouse models of HH show bone loss, suggesting that iron overload alone may not suffice to induce bone loss. In this study, the bone phenotypes of Hjv-/- and hepatocyte-specific Alk2- and Alk3-deficient mice as additional mouse models of HH were...
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