Article
Sex-specific characterization of a novel metabolic osteoporosis phenotype induced by NOS-inhibition and Western diet in Wistar rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Feb 2026
Kloock Simon, Zytner Palina, Lunkwitz Tom, Geiger Niklas, Sequeira Vasco, Maack Christoph, Kurlbaum Max, Sarwar Humma, Ignatius Anita, Fassnacht Martin, Haffner-Luntzer Melanie, Dischinger Ulrich
Abstract excerpt
BACKGROUND: Multiple aspects of the metabolic syndrome are linked to impaired bone health, yet most animal models address only single contributing factors. Here, a male and female "two-hit" rat model of metabolic osteoporosis combining a high-fat/high-fructose "Western" diet (WD) and N(ω)-nitro-L-arginine-methyl-ester (L-NAME) is introduced and characterized. METHODS: Female Wistar rats were randomized into three...
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