Article

PNPLA3 <sup>I148M</sup> is a novel regulator of bone mass independent of MASLD

2026-03-17

Abstract excerpt

<h4>ABSTRACT</h4> Metabolic-dysfunction associated steatotic liver disease (MASLD) is the most common chronic liver disease. Fracture risk is increased among people with MASLD, however, the genetic contribution to risk is undetermined. PNPLA3 I148M is a common SNP which accounts for most MASLD heritability and increases MASLD morbidity and mortality. However, PNPLA3 I148M impact on bone is unexplored. To bridge...

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Literature Corpus work: 4e75bda2-4428-5553-9108-a7a0af0c4d4a
DOI: 10.64898/2026.03.13.711662

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