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Lineage tracing of T cell differentiation from T-iPSC by 2D feeder-free culture and 3D organoid culture

15 Dec 2023

Abstract excerpt

Introduction: T cells induced from induced pluripotent stem cells(iPSCs) derived from antigen-specific T cells (T-iPS-T cells) are an attractive tool for T cell immunotherapy. The induction of cytotoxic T-iPS-T cells is well established in feeder-free condition for the aim of off-the-shelf production, however, the induction of helper T-iPS-T cells remains challenging. Methods: We analyzed T-iPS-T cells matured in...

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PMID: 38162650
DOI: 10.3389/fimmu.2023.1303713

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