Article

Tunable differentiation of human CD4+ and CD8+ T cells from pluripotent stem cells

2024-11-03

Abstract excerpt

Allogeneic T cell therapies are a highly desirable option to circumvent the cost and complexity of using autologous T cells to treat diseases. Allogeneic CD8+ T cells can be made from pluripotent stem cells (PSCs), but deriving CD4+ T cells from PSCs remained a significant challenge. Using feeder- and serum-free conditions, we found that CD4+ versus CD8+ T cell commitment from PSCs can be controlled by fine-tuning...

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Literature Corpus work: 50790ad5-0483-5ca8-bb79-3d5d5b44b6d0
DOI: 10.1101/2024.10.29.620998

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