Article

GRIMM-II: A Two-Stage Real-Time Algorithm for Nine-Locus HLA Imputation and Matching with Up to Three Mismatches

2026-03-31

Abstract excerpt

<h4>Background</h4> The success of hematopoietic stem cell transplantation (HSCT) depends critically on human leukocyte antigen (HLA) matching between donor and recipient. While traditional matching focuses on five classical HLA loci (A, B, C, DRB1, DQB1), clinical practice increasingly considers extended typing at nine loci, including DPA1, DQA1, DPB1, and DRB3/4/5. Furthermore, emerging evidence supports transp...

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Literature Corpus work: 74bc24f6-fe0b-5890-9bd5-8933a310efd1
DOI: 10.64898/2026.03.28.715027

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GRIMM-II: A Two-Stage Real-Time Algorithm for Nine-Locus HLA Imputation and Matching with Up to Three MismatchesDOI 10.64898/2026.03.28.715027Read

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