Article
Predicting HLA-DPB1 permissive probabilities through a DPB1 prediction service towards the optimization of HCT donor selection.
Human immunology - 1 Dec 2021
Sajulga Ray, Madbouly Abeer, Fingerson Stephanie, Gragert Loren, Bashyal Pradeep, Bolon Yung-Tsi, Maiers Martin
Abstract excerpt
Despite its demonstrated importance in hematopoietic cell transplantation, the HLA-DPB1 locus is only typed in one in five unrelated donors in the United States. Addressing this issue, we developed a DPB1 Prediction Service that leverages seven-locus haplotype frequencies (HLA-A ∼ C ∼ B ∼ DRB3/4/5 ∼ DRB1 ∼ DQB1 ∼ DPB1) to extend the imputation of six-locus HLA typing (HLA-A ∼ C ∼ B ∼ DRB3/4/5 ∼ DRB1 ∼ DQB1) to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.