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Combined imputation of HLA genotype and self-identified race leads to better donor-recipient matching.

Human immunology - 1 Dec 2023

Israeli Sapir, Gragert Loren, Madbouly Abeer, Bashyal Pradeep, Schneider Joel, Maiers Martin, Louzoun Yoram

Abstract excerpt

Allogeneic Hematopoietic Cell Transplantation (HCT) is a curative therapy for hematologic disorders and often requires human leukocyte antigen (HLA)-matched donors. Donor registries have recruited donors utilizing evolving technologies of HLA genotyping methods. This necessitates in-silico ambiguity resolution and statistical imputation based on haplotype frequencies estimated from donor data stratified by...

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Identifiers

PMID: 37867095
DOI: 10.1016/j.humimm.2023.110721
PMCID: PMC10842039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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