Enhancing Kidney Transplant Success: Simulation of Prospective Pirche-Ii Molecular Matching in Canada

Abstract excerpt

<title>Abstract</title> <p>Organ allocation to minimize Human Leukocyte Antigens (HLA) disparity between donor and recipient has been shown to improve outcomes but is limited by the enormous HLA diversity. PIRCHE-II in silico model considers the HLA peptide binding characteristics of recipients to quantitate molecular compatibility. We have applied a simplified match algorithm in a well characterised nested popul...

Topics

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• Algorithms
• Alleles
• Epitopes, T-Lymphocyte
• Graft Rejection
• Histocompatibility Testing
• HLA Antigens
• Renal Transplantation Outcomes and Treatments
• Tissue Donors

Identifiers and source

Literature Corpus work

6d8c2f8d-0aa0-51d3-8bcb-5ad82cfd6694

DOI

10.21203/rs.3.rs-6271914/v1