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Osteoblast suppression in multiple myeloma bone disease

15 Sept 2018

Abstract excerpt

Multiple myeloma (MM) is the most frequent cancer to involve the skeleton with patients developing osteolytic bone lesions due to hyperactivation of osteoclasts and suppression of BMSCs differentiation into functional osteoblasts. Although new therapies for MM have greatly improved survival, MM remains incurable for most patients. Despite the major advances in current anti-MM and anti-resorptive treatments that...

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PMID: 30591859
DOI: 10.1016/j.jbo.2018.09.001

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